Research led by the University of Birmingham and the University of Birmingham Women’s and Children’s NHS Foundation Trust has explored new insights into the biological mechanisms of the long-term positive health effects of breastfeeding to prevent immune system disorders in later life.
Breastfeeding is thought to be associated with better health outcomes in early stages and into adulthood, and previous research has shown that breastfed infants are less likely to develop asthma, obesity, and autoimmune diseases later in life. , Which is especially in life compared to formula-fed.
However, until now, the immune mechanisms responsible for these effects have been poorly understood. In this new study, researchers first discovered that a specific type of immune cells – called regulatory T cells – expanded into breastfed human infants in the first three weeks of life and compared to formula-fed infants. Is almost double in These cells also regulate the child’s immune response against the transferred maternal cells with breastmilk and help reduce inflammation.
In addition, the research – supported by the National Institute for Health Research Surgical Reconstruction and Microbiology Research Center (NIHR SRMRC) – has shown that specific bacteria, called violinella and jamella, that support the function of regulatory T cells, Are more abundant in the intestine. Breastfeeding Children.
The study’s results, published in Allergy, emphasize the importance of breastfeeding, the researchers say.
Gergelli Toldi, a researcher at the University of Birmingham and a senior author of the Neonatologist, an advisor to the NHS Foundation Trust for Birmingham Women and Children, said: “The effect of the type of milk obtained on the development of the immune response has not previously been studied. A few weeks of life.
“Prior to our research, the outstanding importance and initial involvement of this specific cell type in breastfed infants was unknown.
“We hope that this invaluable new insight will increase breastfeeding rates and more babies will benefit from the benefits of breast feeding.
“Furthermore, we hope for children who are formula-fed, these results will contribute to optimizing the structure of formula milk to exploit these immune mechanisms.
“We are very grateful to the mothers and babies who contributed to this special project.”
The study is the culmination of a unique three-year research project analyzing data from 38 healthy mothers and their healthy infants. Small amounts of blood and fecal samples were collected at birth at Birmingham Women’s Hospital and then later during a home visit when the children were three weeks old. Sixteen of 38 infants (42%) were exclusively breastfed for the duration of the study, while nine infants received a mixed diet, and 13 infants were fed exclusively formula.
Researchers hope that this biological mechanism will now be studied in sick and pre-neonates who have developed inflammatory complications. (ANI)
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